diff --git a/.circleci/config.yml b/.circleci/config.yml
index c8b82bc85..8b05dfcaa 100644
--- a/.circleci/config.yml
+++ b/.circleci/config.yml
@@ -147,6 +147,9 @@ workflows:
       - test-e2e-firefox:
           requires:
             - prep-build-test
+      - test-e2e-chrome-rpc:
+          requires:
+            - prep-build-test
       - test-e2e-chrome-snaps:
           requires:
             - prep-build-test-flask
@@ -803,6 +806,43 @@ jobs:
           path: test-artifacts
           destination: test-artifacts
 
+  test-e2e-chrome-rpc:
+    executor: node-browsers
+    parallelism: 1
+    steps:
+      - checkout
+      - run:
+          name: Re-Install Chrome
+          command: ./.circleci/scripts/chrome-install.sh
+      - attach_workspace:
+          at: .
+      - run:
+          name: Move test build to dist
+          command: mv ./dist-test ./dist
+      - run:
+          name: Move test zips to builds
+          command: mv ./builds-test ./builds
+      - run:
+          name: test:e2e:chrome:rpc
+          command: |
+            if .circleci/scripts/test-run-e2e.sh
+            then
+              yarn test:e2e:chrome:rpc --retries 2
+            fi
+          no_output_timeout: 20m
+      - run:
+          name: Merge JUnit report
+          command: |
+            if [ "$(ls -A test/test-results/e2e)" ]; then
+              yarn test:e2e:report
+            fi
+          when: always
+      - store_artifacts:
+          path: test-artifacts
+          destination: test-artifacts
+      - store_test_results:
+          path: test/test-results/e2e.xml
+
   test-e2e-firefox-snaps:
     executor: node-browsers
     parallelism: 4
diff --git a/package.json b/package.json
index 380171a7b..a8cabd934 100644
--- a/package.json
+++ b/package.json
@@ -37,6 +37,7 @@
     "test:e2e:chrome": "SELENIUM_BROWSER=chrome node test/e2e/run-all.js",
     "test:e2e:chrome:snaps": "SELENIUM_BROWSER=chrome node test/e2e/run-all.js --snaps",
     "test:e2e:chrome:mv3": "SELENIUM_BROWSER=chrome node test/e2e/run-all.js --mv3",
+    "test:e2e:chrome:rpc": "SELENIUM_BROWSER=chrome node test/e2e/run-all.js --rpc",
     "test:e2e:firefox": "SELENIUM_BROWSER=firefox node test/e2e/run-all.js",
     "test:e2e:firefox:snaps": "SELENIUM_BROWSER=firefox node test/e2e/run-all.js --snaps",
     "test:e2e:single": "node test/e2e/run-e2e-test.js",
diff --git a/test/e2e/json-rpc/eth_call.spec.js b/test/e2e/json-rpc/eth_call.spec.js
new file mode 100644
index 000000000..592a298ff
--- /dev/null
+++ b/test/e2e/json-rpc/eth_call.spec.js
@@ -0,0 +1,67 @@
+const { strict: assert } = require('assert');
+const { keccak256 } = require('@truffle/codec/dist/lib/evm/utils');
+const { convertToHexValue, withFixtures } = require('../helpers');
+const { SMART_CONTRACTS } = require('../seeder/smart-contracts');
+const FixtureBuilder = require('../fixture-builder');
+
+describe('eth_call', function () {
+  const smartContract = SMART_CONTRACTS.NFTS;
+  const ganacheOptions = {
+    accounts: [
+      {
+        secretKey:
+          '0x7C9529A67102755B7E6102D6D950AC5D5863C98713805CEC576B945B15B71EAC',
+        balance: convertToHexValue(25000000000000000000),
+      },
+    ],
+  };
+  it('executes a new message call', async function () {
+    await withFixtures(
+      {
+        dapp: true,
+        fixtures: new FixtureBuilder()
+          .withPermissionControllerConnectedToTestDapp()
+          .build(),
+        ganacheOptions,
+        smartContract,
+        title: this.test.title,
+      },
+      async ({ driver, _, contractRegistry }) => {
+        const contract = contractRegistry.getContractAddress(smartContract);
+        await driver.navigate();
+        await driver.fill('#password', 'correct horse battery staple');
+        await driver.press('#password', driver.Key.ENTER);
+
+        // eth_call
+        await driver.openNewPage(`http://127.0.0.1:8080`);
+        const balanceOf = `0x${keccak256('balanceOf(address)').toString(
+          'hex',
+        )}`;
+        const walletAddress = '0x5cfe73b6021e818b776b421b1c4db2474086a7e1';
+        const request = JSON.stringify({
+          jsonrpc: '2.0',
+          method: 'eth_call',
+          params: [
+            {
+              to: `${contract}`,
+              data:
+                `${balanceOf.slice(0, 10)}` +
+                '000000000000000000000000' +
+                `${walletAddress.substring(2)}`,
+            },
+            'latest',
+          ],
+          id: 0,
+        });
+        const result = await driver.executeScript(
+          `return window.ethereum.request(${request})`,
+        );
+
+        assert.equal(
+          result,
+          '0x0000000000000000000000000000000000000000000000000000000000000001',
+        );
+      },
+    );
+  });
+});
diff --git a/test/e2e/json-rpc/eth_chainId.spec.js b/test/e2e/json-rpc/eth_chainId.spec.js
new file mode 100644
index 000000000..d86ccea60
--- /dev/null
+++ b/test/e2e/json-rpc/eth_chainId.spec.js
@@ -0,0 +1,46 @@
+const { strict: assert } = require('assert');
+const { convertToHexValue, withFixtures } = require('../helpers');
+const FixtureBuilder = require('../fixture-builder');
+
+describe('eth_chainId', function () {
+  const ganacheOptions = {
+    accounts: [
+      {
+        secretKey:
+          '0x7C9529A67102755B7E6102D6D950AC5D5863C98713805CEC576B945B15B71EAC',
+        balance: convertToHexValue(25000000000000000000),
+      },
+    ],
+  };
+  it('returns the chain ID of the current network', async function () {
+    await withFixtures(
+      {
+        dapp: true,
+        fixtures: new FixtureBuilder()
+          .withPermissionControllerConnectedToTestDapp()
+          .build(),
+        ganacheOptions,
+        title: this.test.title,
+      },
+      async ({ driver }) => {
+        await driver.navigate();
+        await driver.fill('#password', 'correct horse battery staple');
+        await driver.press('#password', driver.Key.ENTER);
+
+        // eth_chainId
+        await driver.openNewPage(`http://127.0.0.1:8080`);
+        const request = JSON.stringify({
+          jsonrpc: '2.0',
+          method: 'eth_chainId',
+          params: [],
+          id: 0,
+        });
+        const result = await driver.executeScript(
+          `return window.ethereum.request(${request})`,
+        );
+
+        assert.equal(result, '0x539');
+      },
+    );
+  });
+});
diff --git a/test/e2e/json-rpc/eth_sendTransaction.spec.js b/test/e2e/json-rpc/eth_sendTransaction.spec.js
new file mode 100644
index 000000000..90da37a4b
--- /dev/null
+++ b/test/e2e/json-rpc/eth_sendTransaction.spec.js
@@ -0,0 +1,121 @@
+const { strict: assert } = require('assert');
+const { convertToHexValue, withFixtures } = require('../helpers');
+const FixtureBuilder = require('../fixture-builder');
+
+describe('eth_sendTransaction', function () {
+  const ganacheOptions = {
+    hardfork: 'london',
+    accounts: [
+      {
+        secretKey:
+          '0x7C9529A67102755B7E6102D6D950AC5D5863C98713805CEC576B945B15B71EAC',
+        balance: convertToHexValue(25000000000000000000),
+      },
+    ],
+  };
+  const expectedHash =
+    '0x855951a65dcf5949dc54beb032adfb604c52a0a548a0f616799d6873a9521470';
+  it('confirms a new transaction', async function () {
+    await withFixtures(
+      {
+        dapp: true,
+        fixtures: new FixtureBuilder()
+          .withPermissionControllerConnectedToTestDapp()
+          .build(),
+        ganacheOptions,
+        title: this.test.title,
+      },
+      async ({ driver }) => {
+        await driver.navigate();
+        await driver.fill('#password', 'correct horse battery staple');
+        await driver.press('#password', driver.Key.ENTER);
+
+        // eth_sendTransaction
+        await driver.openNewPage(`http://127.0.0.1:8080`);
+        const request = JSON.stringify({
+          jsonrpc: '2.0',
+          method: 'eth_sendTransaction',
+          params: [
+            {
+              to: '0x5cfe73b6021e818b776b421b1c4db2474086a7e1',
+              from: '0x5cfe73b6021e818b776b421b1c4db2474086a7e1',
+              value: '0x0',
+              maxPriorityFeePerGas: '0x3b9aca00',
+              maxFeePerGas: '0x2540be400',
+            },
+          ],
+          id: 0,
+        });
+        await driver.executeScript(
+          `window.transactionHash = window.ethereum.request(${request})`,
+        );
+
+        // confirm transaction in mm popup
+        await driver.waitUntilXWindowHandles(3);
+        await driver.switchToWindowWithTitle('MetaMask Notification');
+        await driver.clickElement({ text: 'Confirm', tag: 'button' });
+        await driver.switchToWindowWithTitle('E2E Test Dapp');
+        const actualHash = await driver.executeScript(
+          `return window.transactionHash;`,
+        );
+        assert.equal(actualHash, expectedHash);
+      },
+    );
+  });
+  it('rejects a new transaction', async function () {
+    await withFixtures(
+      {
+        dapp: true,
+        fixtures: new FixtureBuilder()
+          .withPermissionControllerConnectedToTestDapp()
+          .build(),
+        ganacheOptions,
+        title: this.test.title,
+      },
+      async ({ driver }) => {
+        await driver.navigate();
+        await driver.fill('#password', 'correct horse battery staple');
+        await driver.press('#password', driver.Key.ENTER);
+
+        // eth_sendTransaction
+        await driver.openNewPage(`http://127.0.0.1:8080`);
+        const request = JSON.stringify({
+          jsonrpc: '2.0',
+          method: 'eth_sendTransaction',
+          params: [
+            {
+              to: '0x5cfe73b6021e818b776b421b1c4db2474086a7e1',
+              from: '0x5cfe73b6021e818b776b421b1c4db2474086a7e1',
+              value: '0x0',
+              maxPriorityFeePerGas: '0x3b9aca00',
+              maxFeePerGas: '0x2540be400',
+            },
+          ],
+          id: 0,
+        });
+        await driver.executeScript(
+          `window.transactionHash = window.ethereum.request(${request})`,
+        );
+
+        // reject transaction in mm popup
+        await driver.waitUntilXWindowHandles(3);
+        await driver.switchToWindowWithTitle('MetaMask Notification');
+        await driver.clickElement({ text: 'Reject', tag: 'button' });
+        await driver.switchToWindowWithTitle('E2E Test Dapp');
+        const result = await driver
+          .executeScript(`return window.transactionHash;`)
+          .then((data) => {
+            return data;
+          })
+          .catch((err) => {
+            return err;
+          });
+        assert.ok(
+          result.message.includes(
+            'MetaMask Tx Signature: User denied transaction signature.',
+          ),
+        );
+      },
+    );
+  });
+});
diff --git a/test/e2e/run-all.js b/test/e2e/run-all.js
index d045233e5..d97d6c8a1 100644
--- a/test/e2e/run-all.js
+++ b/test/e2e/run-all.js
@@ -50,6 +50,10 @@ async function main() {
             description: `run mv3 specific e2e tests`,
             type: 'boolean',
           })
+          .option('rpc', {
+            description: `run json-rpc specific e2e tests`,
+            type: 'boolean',
+          })
           .option('retries', {
             description:
               'Set how many times the test should be retried upon failure.',
@@ -59,13 +63,16 @@ async function main() {
     .strict()
     .help('help');
 
-  const { browser, debug, retries, snaps, mv3 } = argv;
+  const { browser, debug, retries, snaps, mv3, rpc } = argv;
 
   let testPaths;
 
   if (snaps) {
     const testDir = path.join(__dirname, 'snaps');
     testPaths = await getTestPathsForTestDir(testDir);
+  } else if (rpc) {
+    const testDir = path.join(__dirname, 'json-rpc');
+    testPaths = await getTestPathsForTestDir(testDir);
   } else {
     const testDir = path.join(__dirname, 'tests');
     testPaths = [